It is the latest landmark in a remarkable career and comes less than 11 years after the then 17-year-old's first senior goal against Albacete in May 2005.
Messi is Barcelona's all-time leading scorer, and he also tops the charts in La Liga history, with 309 goals putting him well ahead of Real Madrid's Cristiano Ronaldo on 256.
"The figure is from another galaxy," said Barca boss Luis Enrique when asked about the achievement.
Twelve seasons and 631 games as a professional. That’s what Messi needed to reach 500 career goals, with 450 of them coming for his club and the other 50 for Argentina.
LIONEL MESSI’S 500 GOALS, SEASON BY SEASON
2004/05: 1 Goal with Barça/ 0 Goals with Argentina/ 1 Goal
2005/06: 8 Goals with Barça/ 2 Goals con Argentina/ 10 Goals
2006/07: 17 Goals with Barça/ 4 Goals with Argentina/ 21 Goals
2007/08: 16 Goals with Barça/ 3 Goals with Argentina/ 19 Goals
2008/09: 38 Goals with Barça/ 3 Goals with Argentina/ 41 Goals
2009/10: 47 Goals with Barça/ 1 Goal with Argentina/ 48 Goals
2010/11: 53 Goals with Barça/ 4 Goals with Argentina/ 57 Goals
2011/12: 73 Goals with Barça/ 9 Goals with Argentina/ 82 Goals
2012/13: 60 Goals with Barça/ 9 Goals with Argentina/ 69 Goals
2013/14: 41 Goals with Barça/ 7 Goals with Argentina/ 48 Goals
2014/15: 58 Goals with Barça/ 4 Goals with Argentina/ 62 Goals
2015/16: 38 Goals with Barça/ 4 Goals with Argentina/ 42 Goals
TOTAL: 450 GOALS WITH BARÇA/ 50 GOALS WITH ARGENTINA/ 500 GOALS
